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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF4A
All Species:
30.3
Human Site:
Y446
Identified Species:
55.56
UniProt:
P41235
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41235
NP_849180.1
474
52785
Y446
G
G
S
G
S
E
P
Y
K
L
L
P
G
A
V
Chimpanzee
Pan troglodytes
XP_514664
468
51900
Y440
G
G
S
G
S
E
P
Y
K
L
L
P
G
A
V
Rhesus Macaque
Macaca mulatta
XP_001110097
452
49945
Y424
G
G
S
G
S
E
P
Y
K
L
L
P
G
A
V
Dog
Lupus familis
XP_852731
474
52640
Y446
G
G
S
G
S
E
P
Y
K
L
L
P
G
A
I
Cat
Felis silvestris
Mouse
Mus musculus
P49698
474
52665
Y446
S
G
S
G
S
E
S
Y
K
L
L
P
G
A
I
Rat
Rattus norvegicus
P22449
474
52693
Y446
S
G
S
G
S
E
S
Y
K
L
L
P
G
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507309
419
46844
H392
T
H
H
P
L
H
P
H
L
M
Q
E
N
M
G
Chicken
Gallus gallus
NP_001026026
454
50607
Y426
A
G
S
G
P
E
Q
Y
K
L
L
P
G
A
I
Frog
Xenopus laevis
Q91766
464
51948
Y436
A
G
S
G
A
E
Q
Y
K
I
V
H
G
T
I
Zebra Danio
Brachydanio rerio
A2T929
430
47452
E402
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49866
666
71882
T578
S
R
S
G
P
L
P
T
Q
H
S
P
Q
R
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O44960
369
41820
D342
L
F
G
L
A
S
I
D
N
L
M
L
E
L
M
Sea Urchin
Strong. purpuratus
XP_780389
468
51669
P439
P
A
T
A
T
A
G
P
P
A
P
A
A
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.6
90.9
98.3
N.A.
95.7
96.1
N.A.
79.5
84.1
80.8
33.7
N.A.
42.4
N.A.
33.9
57.1
Protein Similarity:
100
82.9
91.9
99.1
N.A.
97
97.4
N.A.
84.8
89.8
89.6
51.4
N.A.
54.5
N.A.
49.5
72.3
P-Site Identity:
100
100
100
93.3
N.A.
80
80
N.A.
6.6
73.3
46.6
6.6
N.A.
26.6
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
20
80
73.3
13.3
N.A.
40
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
8
0
8
16
8
0
0
0
8
0
8
8
54
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
62
0
8
0
0
0
8
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
8
8
8
0
0
% F
% Gly:
31
62
16
70
0
0
8
0
0
0
0
0
62
0
8
% G
% His:
0
8
8
0
0
8
0
8
8
8
0
8
0
0
0
% H
% Ile:
0
8
0
0
0
0
8
0
0
8
0
0
0
0
39
% I
% Lys:
0
0
0
0
8
0
0
0
62
0
0
0
0
8
0
% K
% Leu:
8
0
0
16
8
8
8
0
8
70
54
8
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
8
0
0
8
16
% M
% Asn:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% N
% Pro:
8
0
0
8
16
0
47
8
8
0
8
62
0
0
0
% P
% Gln:
0
0
0
0
0
0
16
0
8
0
8
0
8
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
31
0
70
0
47
8
16
0
0
0
8
0
0
0
0
% S
% Thr:
8
0
8
0
8
0
0
8
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _